foscarnet   Click here for help

GtoPdb Ligand ID: 5497

Synonyms: carboxyphosphonic acid | Foscavir® | phosphonocarboxylic acid | phosphonoformic acid
Approved drug PDB Ligand
foscarnet is an approved drug (FDA (1991))
Compound class: Synthetic organic
Comment: Foscarnet is an antiviral medication.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 1
Topological polar surface area 104.64
Molecular weight 125.97
XLogP -2.13
No. Lipinski's rules broken 0
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Canonical SMILES OC(=O)P(=O)(O)O
Isomeric SMILES OC(=O)P(=O)(O)O
InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)
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Summary of Clinical Use Click here for help
Foscarnet is used to treat cytomegalovirus retinitis in people with AIDS and to treat herpes simplex virus in immunocompromised patients.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Foscarnet prevents viral replication by selectively inhibiting the pyrophosphate binding site on virus-specific DNA polymerases. This drug does not affect host cell DNA polymerases at therapeutic concentrations.