naphazoline   Click here for help

GtoPdb Ligand ID: 5509

Synonyms: Naphcon®
Approved drug
naphazoline is an approved drug (FDA (1971, prior history not available))
Compound class: Synthetic organic
Comment: Marketed formulations may contain naphazoline hydrochloride (PubChem CID 11079) or naphazoline nitrate (PubChem CID 16218420).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 24.39
Molecular weight 210.12
XLogP 2.77
No. Lipinski's rules broken 0
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Canonical SMILES C1CN=C(N1)Cc1cccc2c1cccc2
Isomeric SMILES C1CN=C(N1)Cc1cccc2c1cccc2
InChI InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16)
No information available.
Summary of Clinical Use Click here for help
Naphazoline is a vasoconstrictor which temporarily reduces eye redness by narrowing swollen blood vessels in the eyes.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Agonism of the α-adrenoceptors in the nasal muscosa results in vasoconstriction leading to decreased blood flow and decreased nasal congestion. However, we have been unable to find affinity data for this drug to substantiate its MMOA.
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