Synonyms: GSK 461364 | GSK-461364 | GSK461364 | GSK461364A
Compound class:
Synthetic organic
Comment: GSK-461364A is an inhibitor of polo-like kinase 1 (PLK1) [2]. It was tested in preclinical studies.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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No information available. |
Summary of Clinical Use |
A Phase 1 clinical trial assessing the pharmacokinetics and pharmacodynamics of GSK-461364A in patients with non-Hodgkins lymphoma has been completed (see NCT00536835). |