Ligand id: 5706

Name: tamatinib

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 128.75
Molecular weight 470.17
XLogP 2.72
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Tamatinib is a potential drug for treatment of the inflammation associated with and causing bronchial asthma resulting from allergen-induced airway hyperresponsiveness (AHR). The compound may have beneficial effects in additional inflammatory conditions, such as rheumatoid arthritis and other autoimmune conditions.
Mechanism Of Action and Pharmacodynamic Effects
Tamatinib is a potent ATP-competitive inhibitor of spleen tyrosine kinase (SYK). SYK plays an essential role in the signal-transduction cascade which leads to mast cell degranulation and cytokine release in inflammatory bronchial asthma [1]. Tamatinib can reduce the pathological results of airway hyperresponsiveness (AHR).