Ligand id: 5758

Name: casopitant

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 9
Topological polar surface area 47.1
Molecular weight 616.26
XLogP 5.96
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Casopitant has completed Phase III clinical trials evaluating its utility as an antiemetic for the treatment of chemotherapy-induced nausea and vomiting. Phase II clinical trials for insomnia, major depressive disorder (MDD) and anxiety disorders have also been completed. Click here to link to's complete list of casopitant trials, and here to link to GSK's list of clinical trials evaluating this compound (hosted on the GSK clinical study register).