sufinpyrazone   Click here for help

GtoPdb Ligand ID: 5826

Synonyms: Anturane® | Apo-sulfinpyrazone® | G 28315 | NSC 75925 | suphinpyrazone
Approved drug
sufinpyrazone is an approved drug (FDA (1959))
Compound class: Synthetic organic
Comment: Sufinpyrazone is a uricosuric anti-gout medication, i.e. it increases excretion of uric acid in the urine.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 76.9
Molecular weight 404.12
XLogP 2.4
No. Lipinski's rules broken 0
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Canonical SMILES O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1
Isomeric SMILES O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1
InChI InChI=1S/C23H20N2O3S/c26-22-21(16-17-29(28)20-14-8-3-9-15-20)23(27)25(19-12-6-2-7-13-19)24(22)18-10-4-1-5-11-18/h1-15,21H,16-17H2
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Summary of Clinical Use Click here for help
Used to reduce the serum urate levels in patients with gout. The marketing authorisation for Anturane® in the US has been discontinued.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Competitively inhibits reabsorption of uric acid at the proximal convoluted tubul, facilitating urinary excretion of uric acid and decreasing plasma urate concentrations.