olmesartan   Click here for help

GtoPdb Ligand ID: 591

Synonyms: Benicar® | CS-866 | Olmetec®
Approved drug
olmesartan is an approved drug (FDA (2002))
Compound class: Synthetic organic
Comment: Marketed formulations may contain olmesartan medoxomil (PubChem CID 130881).
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View more information in the IUPHAR Pharmacology Education Project: olmesartan

2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 162.16
Molecular weight 558.22
XLogP 5.55
No. Lipinski's rules broken 2
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Canonical SMILES CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C
Isomeric SMILES CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C
InChI InChI=1S/C29H30N6O6/c1-5-8-23-30-25(29(3,4)38)24(27(36)39-16-22-17(2)40-28(37)41-22)35(23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)26-31-33-34-32-26/h6-7,9-14,38H,5,8,15-16H2,1-4H3,(H,31,32,33,34)
No information available.
Summary of Clinical Use Click here for help
Used in the treatment of hypertension.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Inhibition of the binding of angiotensin II to the AT1 receptor by olmesartan inhibits the AT1-mediated vasocontrictive and aldosterone-secreting effects of angiotensin II and results in a decrease in vascular resistance and blood pressure.
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