imidapril   

GtoPdb Ligand ID: 6377

Synonyms: imidapril hydrochloride
imidapril is an approved drug
Compound class: Synthetic organic
Comment: Imidapril is an ACE inhibitor, administered as a prodrug which is then metabolised to the active form, imidaprilat.
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 116.25
Molecular weight 405.19
XLogP 1.05
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES CCOC(=O)C(NC(C(=O)N1C(=O)N(CC1C(=O)O)C)C)CCc1ccccc1
Isomeric SMILES CCOC(=O)[C@@H](N[C@H](C(=O)N1C(=O)N(C[C@H]1C(=O)O)C)C)CCc1ccccc1
InChI InChI=1S/C20H27N3O6/c1-4-29-19(27)15(11-10-14-8-6-5-7-9-14)21-13(2)17(24)23-16(18(25)26)12-22(3)20(23)28/h5-9,13,15-16,21H,4,10-12H2,1-3H3,(H,25,26)/t13-,15-,16-/m0/s1
InChI Key KLZWOWYOHUKJIG-BPUTZDHNSA-N
No information available.
Summary of Clinical Use
Imidapril is used to treat hypotension and chronic heart failure. There is no information regarding approval for medical use of imidapril on the US FDA website. Individual national agencies may have granted marketing approval.
Mechanism Of Action and Pharmacodynamic Effects
See our entry for imidaprilat for mecahnism of action details.