moexiprilat   Click here for help

GtoPdb Ligand ID: 6572

Synonyms: RS-10029
Approved drug
moexiprilat is an approved drug
Compound class: Synthetic organic
Comment: Moexiprilat is the in vivo formed, active form of the prodrug moexipril. Moexiprilat is an ACE inhibitor.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 125.4
Molecular weight 470.21
XLogP 1.98
No. Lipinski's rules broken 0
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Canonical SMILES COc1cc2CC(C(=O)O)N(Cc2cc1OC)C(=O)C(NC(C(=O)O)CCc1ccccc1)C
Isomeric SMILES COc1cc2C[C@@H](C(=O)O)N(Cc2cc1OC)C(=O)[C@@H](N[C@H](C(=O)O)CCc1ccccc1)C
InChI InChI=1S/C25H30N2O7/c1-15(26-19(24(29)30)10-9-16-7-5-4-6-8-16)23(28)27-14-18-13-22(34-3)21(33-2)12-17(18)11-20(27)25(31)32/h4-8,12-13,15,19-20,26H,9-11,14H2,1-3H3,(H,29,30)(H,31,32)/t15-,19-,20-/m0/s1
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Summary of Clinical Use Click here for help
The approved drug moexipril is administered for the treatment of hypertension.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
An inhibitor of angiotensin-converting enzyme. This inhibition prevents the conversion of angiotensin I to angiotensin II, thereby reducing the vasoconstriction and aldosterone secretion stimulated by angiotensin II. Also causes increased plasma renin activity. However, we have been unable to find molecular data for this drug at the human target, to substantiate its MMOA.