Ligand id: 6805

Name: decitabine

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 123.49
Molecular weight 228.09
XLogP -1.21
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat patients with myelodysplastic syndrome (MDS)
Mechanism Of Action and Pharmacodynamic Effects
A chemical analogue of cytidine which inhibits methylation in DNA/RNA into which it is incorporated, adversely affecting DNA/RNA binding by regulatory proteins.