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Synonyms: Clexane® | enoxaparin sodium | Lovenox® | PK-10169 | RP-54563
enoxaparin is an approved drug (FDA (1993), FDA (2016))
Compound class: Synthetic organic
Comment: A Low-Molecular-Weight Heparin antithrombin-III activator. It consists of fractionated material from pig mucosa but the PubChem structure represents the major form.
Biosimilar drugs: The EMA approved enoxaparin biosimilars named Inhixa and Thorinane in 2016.
View more information in the IUPHAR Pharmacology Education Project: enoxaparin
|No information available.|
|Summary of Clinical Use|
|Used to prevent and treat deep vein thrombosis or pulmonary embolism, and is given as a subcutaneous injection.
SARS-CoV-2 and COVID-19: Based on scientific evidence that heparin is a potential target (attachment factor) for SARS-CoV  and other coronaviruses , and in reponse to the observed thrombotic pathology in COVID-19 patients, a clinical trial has been initiated in Italy (March 2020) to determine the efficacy of early treatment with enoxaparin in COVID-19 patients.
|Mechanism Of Action and Pharmacodynamic Effects|
|A low molecular weight heparin; binds to and accelerates the activity of antithrombin III and ultimately prevents fibrin clot formation.|
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)
European Medicines Agency (EMA)