phenindione   Click here for help

GtoPdb Ligand ID: 6838

Synonyms: Dindevan® | phenylindanedione
Approved drug PDB Ligand
phenindione is an approved drug (FDA (approval date not available))
Compound class: Synthetic organic
Comment: Vitamin K epoxide reductase complex subunit 1 isoform 1 inhibitor
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 34.14
Molecular weight 222.07
XLogP 2.72
No. Lipinski's rules broken 0
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Canonical SMILES O=C1C(c2ccccc2)C(=O)c2c1cccc2
Isomeric SMILES O=C1C(c2ccccc2)C(=O)c2c1cccc2
InChI InChI=1S/C15H10O2/c16-14-11-8-4-5-9-12(11)15(17)13(14)10-6-2-1-3-7-10/h1-9,13H
No information available.
Summary of Clinical Use Click here for help
Anticoagulant-discontinued due to higher incidence of severe adverse effects than warfarin. There is no information regarding approval for clinical use of this drug on the US FDA or European Medicines Agency websites. Individual national agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Vitamin K antagonist