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Synonyms: epitomax | Eprontia® (liquid formulation) | MCN-4853 | RWJ-17021 | Topamax®
topiramate is an approved drug (FDA (1996))
Compound class: Synthetic organic
Comment: A multifunctional compound: inhibits carbonic anhydrases II and IV, positively modulates GABA-A receptor anion channels, blocks sodium channel alpha subunits and behaves as an antagonist at the ionotropic glutamate receptors (AMPA and kainate).
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: topiramate
|No information available.
|Summary of Clinical Use
|Used to treat epilepsy in adults and children (including treatment of Lennox-Gastaut syndrome). Also used to prevent migraine. A combination product containing phentermine + extended-release topiramate may be used for the management of obesity (n.b. the EMA refused approval of this combination for this indication in May 2013).
Two small randomized, placebo-controlled pilot studies suggested that the GABA potentiating action of topiramate may be harnessed as a treatment to help reduce alcohol intake in problem drinkers , and as a smoking cessation aid .
|Mechanism Of Action and Pharmacodynamic Effects
|An anticonvulsant drug; enhances GABA-activated chloride channels and inhibits excitatory neurotransmission, through actions on kainate and AMPA receptors.
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)