GtoPdb Ligand ID: 6879

Synonyms: CHI-621 | L04AC02 | SDZ-CHI-621 | Simulect®
basiliximab is an approved drug (FDA (1998), EMA (1998))
Compound class: Antibody
Comment: Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
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Summary of Clinical Use
Prophylaxis of acute organ rejection in adults following cadaveric- or living-donor renal transplantation
Mechanism Of Action and Pharmacodynamic Effects
Abrogates the critical cellular immune response involved in allograft rejection by acting as a functional IL-2 receptor antagonist, thereby inhibiting IL-2-mediated activation of lymphocytes.
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