azilsartan medoxomil   Click here for help

GtoPdb Ligand ID: 6900

Synonyms: Edarbi® | TAK 491
Approved drug
azilsartan medoxomil is an approved drug (EMA & FDA (2011))
Compound class: Synthetic organic
Comment: Azilsartan medoxomil is metabolised into the active form azilsartan. The azilsartan ligand page (accessed via the link above) contains more details of the drug's clinical use and mechanistic action.
The marketed brand, Edarbi®, contains azilsartan medoxomil potassium (PubChem CID 23699544).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 155.59
Molecular weight 568.16
XLogP 6.16
No. Lipinski's rules broken 1
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Canonical SMILES CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)OCc1oc(=O)oc1C
Isomeric SMILES CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)OCc1oc(=O)oc1C
InChI InChI=1S/C30H24N4O8/c1-3-38-28-31-23-10-6-9-22(27(35)39-16-24-17(2)40-30(37)41-24)25(23)34(28)15-18-11-13-19(14-12-18)20-7-4-5-8-21(20)26-32-29(36)42-33-26/h4-14H,3,15-16H2,1-2H3,(H,32,33,36)
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Summary of Clinical Use Click here for help
Prodrug used to treat hypertension.
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