flutamide   Click here for help

GtoPdb Ligand ID: 6943

Synonyms: Eulexin® | SCH-13521
Approved drug
flutamide is an approved drug (FDA (1989))
Compound class: Synthetic organic
Comment: Flutamide is an androgen receptor antagonist.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 72.24
Molecular weight 276.07
XLogP 2.64
No. Lipinski's rules broken 0
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Canonical SMILES O=C(C(C)C)Nc1ccc(c(c1)C(F)(F)F)[N+](=O)[O-]
Isomeric SMILES O=C(C(C)C)Nc1ccc(c(c1)C(F)(F)F)[N+](=O)[O-]
InChI InChI=1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)
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Summary of Clinical Use Click here for help
Flutamide may be used to treat locally confined metastatic prostate cancers.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Flutamide blocks the action of endogenous and exogenous testosterone by binding to the androgen receptor.