Ligand id: 6949

Name: nandrolone

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 37.3
Molecular weight 274.19
XLogP 3.22
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Nandrolone increases production and urinary excretion of erythropoietin and for this property is used to manage refractory deficient red cell production anemias. Nandrolone is also used in the treatment of breast cancer, hereditary angioedema, antithrombin III deficiency, fibrinogen excess, growth failure and Turner's syndrome as well as in the prophylaxis of hereditary angioedema.
Mechanism Of Action and Pharmacodynamic Effects
The drug binds to the androgen receptor and the ligand bound complexes enter the nucleus and bind directly to specific androgen response elements in the promoters of androgen-responsive genes. This alters the transcriptional activity of these genes, the sequelae of which is the observed androgenic effects.