Ligand id: 6957

Name: mitotane

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 0
Molecular weight 317.95
XLogP 6
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat inoperable adrenal cortical carcinoma (ACC), where it specifically causes the death of these cells and inhibits their production of steroid hormones.
Mechanism Of Action and Pharmacodynamic Effects
The precise molecular mechanism underlying mitotane's clinical effects has not been fully resolved, but may include: inhibition of steroidognesis as it is believed to inhibit two of the cytochrome P450 enzymes (CYP11A1 and CYP11B1) [2] essential for initiating steroid hormone biosynthesis and the drug may also cause apoptosis via activation of caspases 3 and 7 [1].
External links