calcitonin (salmon)   

GtoPdb Ligand ID: 6973

Abbreviated name: CT (salmon)
Synonyms: Miacalcin®
calcitonin (salmon) is an approved drug (FDA (1978))
Comment: A synthetic calcitonin receptor agonist. Salmon calcitonin has actions identical to calcitonins of mammalian origin, but its potency is greater and it is longer acting. The overall effect of calcitonin treatment is an increase in bone mass.
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Summary of Clinical Use
Calcitonin (salmon) is used to treat hypercalcaemia of malignancy, osteitis deformans (Paget's disease of bone), for prevention of acute bone loss due to sudden immobility, and is used to treat postmenopausal osteoporosis in some countries.
Mechanism Of Action and Pharmacodynamic Effects
Calcitonin binds to the calcitonin receptor (found primarily in osteoclasts) and enhances the production of vitamin D producing enzymes. This results in increased calcium retention and enhanced osteogenesis and bone density. Binding of calcitonin to its receptor also activates the adenylyl cyclase and phosphatidyl-inositol-calcium signalling pathways