calcitonin (salmon)   

GtoPdb Ligand ID: 6973

Abbreviated name: CT (salmon)
Synonyms: Miacalcin®
calcitonin (salmon) is an approved drug (FDA (1978))
Comment: A synthetic calcitonin receptor agonist. Salmon calcitonin has actions identical to calcitonins of mammalian origin, but its potency is greater and it is longer acting. The overall effect of calcitonin treatment is an increase in bone mass.
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References
1. Albrandt K, Brady EM, Moore CX, Mull E, Sierzega ME, Beaumont K. (1995)
Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene.
Endocrinology, 136 (12): 5377-84. [PMID:7588285]
2. Christopoulos G, Perry KJ, Morfis M, Tilakaratne N, Gao Y, Fraser NJ, Main MJ, Foord SM, Sexton PM. (1999)
Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product.
Mol. Pharmacol., 56 (1): 235-42. [PMID:10385705]
3. Cohen DP, Nussenzveig DR, Gershengorn MC. (1996)
Iodocalcitonin binds to human calcitonin receptors with higher affinity than calcitonin.
Endocrinology, 137 (10): 4507-10. [PMID:8828514]
4. Gorn AH, Rudolph SM, Flannery MR, Morton CC, Weremowicz S, Wang TZ, Krane SM, Goldring SR. (1995)
Expression of two human skeletal calcitonin receptor isoforms cloned from a giant cell tumor of bone. The first intracellular domain modulates ligand binding and signal transduction.
J Clin Invest., 95: 2680-2691. [PMID:7769107]
5. Pham V, Wade JD, Purdue BW, Sexton PM. (2004)
Spatial proximity between a photolabile residue in position 19 of salmon calcitonin and the amino terminus of the human calcitonin receptor.
J. Biol. Chem., 279 (8): 6720-9. [PMID:14623894]