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Abbreviated name: CT (salmon)
calcitonin (salmon) is an approved drug (FDA (1978))
Compound class: Peptide or derivative
Comment: A synthetic calcitonin receptor agonist. Salmon calcitonin has actions identical to calcitonins of mammalian origin, but its potency is greater and it is longer acting. The overall effect of calcitonin treatment is an increase in bone mass.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: calcitonin salmon
1. Albrandt K, Brady EM, Moore CX, Mull E, Sierzega ME, Beaumont K. (1995)
Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene.
Endocrinology, 136 (12): 5377-84. [PMID:7588285]
2. Christopoulos G, Perry KJ, Morfis M, Tilakaratne N, Gao Y, Fraser NJ, Main MJ, Foord SM, Sexton PM. (1999)
Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product.
Mol Pharmacol, 56 (1): 235-42. [PMID:10385705]
3. Cohen DP, Nussenzveig DR, Gershengorn MC. (1996)
Iodocalcitonin binds to human calcitonin receptors with higher affinity than calcitonin.
Endocrinology, 137 (10): 4507-10. [PMID:8828514]
4. Gorn AH, Rudolph SM, Flannery MR, Morton CC, Weremowicz S, Wang TZ, Krane SM, Goldring SR. (1995)
Expression of two human skeletal calcitonin receptor isoforms cloned from a giant cell tumor of bone. The first intracellular domain modulates ligand binding and signal transduction.
J Clin Invest, 95: 2680-2691. [PMID:7769107]
5. Pham V, Wade JD, Purdue BW, Sexton PM. (2004)
Spatial proximity between a photolabile residue in position 19 of salmon calcitonin and the amino terminus of the human calcitonin receptor.
J Biol Chem, 279 (8): 6720-9. [PMID:14623894]