chlorpheniramine   Click here for help

GtoPdb Ligand ID: 6976

Synonyms: chlorprophenpyridamine maleate | Phenetron® | Teldrin®
Approved drug
chlorpheniramine is an approved drug (FDA (1950))
Compound class: Synthetic organic
Comment: The approved drug is a racemic mixture of stereoisomers; (-)-chlorpheniramine (R-isomer) and (+)-chlorpheniramine (S-isomer). We show the non-isomeric molecule to represent the mixture.
Click here for help
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: chlorphenamine

2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 16.13
Molecular weight 274.12
XLogP 3.24
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C
Isomeric SMILES CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C
InChI InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3
No information available.
Summary of Clinical Use Click here for help
Used to treat the symptoms of allergies.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Blocks the interaction of histamine with the histamine H1 receptor.