Ligand id: 6978

Name: semagacestat

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 98.74
Molecular weight 361.2
XLogP 0.72
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
The Phase 3 trial was stopped because, compared with placebo, semagacestat did not improve cognitive status and patients receiving the higher dose had significant worsening of functional ability. [1]