sermorelin   Click here for help

GtoPdb Ligand ID: 6998

Synonyms: Geref® | sermorelin acetate
Approved drug
sermorelin is an approved drug (FDA (1990))
Comment: Sermorelin is a synthetically produced 29-amino acid peptide (GRF1-29-NH2) representing the amino-terminal segment of endogenous human growth hormone-releasing hormone. The approved drug is the acetate salt of the amidated peptide. For a representation of the chemical structure of this peptide which does not specify stereochemistry, please see CID 16129620.
No information available.
Summary of Clinical Use Click here for help
Sermorelin is used to treat growth hormone deficiency or growth failure in children. Marketing approval for this drug has been discontinued in the US. Individual national approval agencies may continue to grant marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Sermorelin mimics endogenous GHRH activity, binding to and activating the growth hormone releasing hormone receptor leading to the release of growth hormone from pituitary gonadotropes.