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Synonyms: Antepsin® | Carafate®
sucralfate is an approved drug (FDA (1981))
Compound class: Synthetic organic
Comment: Sucralfate is a complex of sucrose, sulfate and aluminum which is basic in nature and has an overall negative charge.
Note that this is a complicated chemical complex. Different chemical databases represent this compound in different ways, all of which are valid. The ChEMBL compound is represented by the entry CHEMBL2367706, with separate aluminium hydroxide ions, whereas the structure we show has these ions in association with the sulphites on the core disaccharide sugar. PubChem CID 70789197 also represents the aluminium hydroxide groups in a different way.
View more information in the IUPHAR Pharmacology Education Project: sucralfate
|No information available.|
|Summary of Clinical Use|
|Used to treat active duodenal ulcers not caused by use of NSAIDs. The drug aids healing only, and does not prevent new ulcer formation.|
|Mechanism Of Action and Pharmacodynamic Effects|
|In the acidic conditions of the duodenum and stomach, the drug forms a viscous, impenetrable layer over the surface of active ulcer sites and protects them from corrosive substances such as stomach acid, enzymes, and bile salts.|
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)