amcinonide   Click here for help

GtoPdb Ligand ID: 7060

Synonyms: CL-34699 | Cyclocort®
Approved drug Immunopharmacology Ligand
amcinonide is an approved drug (FDA (1979))
Compound class: Synthetic organic
Comment: A topically applied corticosteroid.
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 99.13
Molecular weight 502.24
XLogP 2.34
No. Lipinski's rules broken 0
Click here for help
Isomeric SMILES CC(=O)OCC(=O)[C@@]12OC3(O[C@@H]1C[C@@H]1[C@]2(C)C[C@H](O)[C@]2([C@H]1CCC1=CC(=O)C=C[C@]21C)F)CCCC3
InChI InChI=1S/C28H35FO7/c1-16(30)34-15-22(33)28-23(35-26(36-28)9-4-5-10-26)13-20-19-7-6-17-12-18(31)8-11-24(17,2)27(19,29)21(32)14-25(20,28)3/h8,11-12,19-21,23,32H,4-7,9-10,13-15H2,1-3H3/t19-,20-,21-,23+,24-,25-,27-,28+/m0/s1
No information available.
Summary of Clinical Use Click here for help
Used to treat itching and inflammation associated with allergic and other inflammatory skin conditions.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
When an agonist binds to and activates the glucocorticoid receptor, the activated receptor complex translocates to the nucleus where it transactivates glucocorticoid response element (GRE) containing genes. The effect of glucocorticoid action is to up-regulate expression of anti-inflammatory proteins and to suppress activity of pro-inflammatory proteins, leading to a general suppression of the immune system. However, we have been unable to find affinity data for this drug to substantiate this MMOA.
External links Click here for help