Synonyms: Lodotra® | Sterapred®
prednisone is an approved drug (FDA (1955))
Compound class:
Synthetic organic
Comment: Prednisone is a synthetic corticosteroid.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
No information available. |
Summary of Clinical Use |
Used to treat a wide variety of inflammatory conditions. |
Mechanism Of Action and Pharmacodynamic Effects |
As an agonist of the glucocorticoid receptor, prednisone modulates expression of genes containing the glucocorticoid response element (GRE). Although complex, the response appears to include inhibition of the biosynthesis of pro-inflammatory prostaglandins and leukotrienes. |
External links |
For extended ADME data see the following: Electronic Medicines Compendium (eMC) Drugs.com |