atomoxetine   Click here for help

GtoPdb Ligand ID: 7118

Synonyms: LY-139603 | Strattera®
Approved drug
atomoxetine is an approved drug (FDA (2002))
Compound class: Synthetic organic
Comment: Atomoxetine is primarily a norepinephrine (noradrenaline) reuptake inhibitor (NRI), with weak inhibitory effects on SERT (serotonin reuptake), and DAT (dopamine reuptake).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 21.26
Molecular weight 255.16
XLogP 3.95
No. Lipinski's rules broken 0
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Canonical SMILES CNCCC(c1ccccc1)Oc1ccccc1C
Isomeric SMILES CNCC[C@H](c1ccccc1)Oc1ccccc1C
InChI InChI=1S/C17H21NO/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3/t17-/m1/s1
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Summary of Clinical Use Click here for help
Used to treat attention deficit hyperactivity disorder (ADHD).
Mechanism Of Action and Pharmacodynamic Effects Click here for help
In vitro studies suggest that atomoxetine is a selective inhibitor of pre-synaptic norepinephrine transporter (SLC6A2).
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