azatadine   

GtoPdb Ligand ID: 7119

Synonyms: Optimine® | SCH-10649
azatadine is an approved drug (FDA (1977))
Compound class: Synthetic organic
Comment: Azatadine is a first-generation antihistamine and anticholinergic drug. Its marketing has been discontinued in many countries as its use has largely been repleaced by newer and more effective alternatives.
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 16.13
Molecular weight 290.18
XLogP 2.81
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES CN1CCC(=C2c3ccccc3CCc3c2nccc3)CC1
Isomeric SMILES CN1CCC(=C2c3ccccc3CCc3c2nccc3)CC1
InChI InChI=1S/C20H22N2/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19/h2-7,12H,8-11,13-14H2,1H3
InChI Key SEBMTIQKRHYNIT-UHFFFAOYSA-N
No information available.
Summary of Clinical Use
Used to reduce symptoms of allergies (such as sneezing, itching, runny nose and watery eyes, rashes).
Mechanism Of Action and Pharmacodynamic Effects
Azatadine blocks the action of endogenous histamine at the histamine H1 receptor.