bendroflumethiazide   Click here for help

GtoPdb Ligand ID: 7122

Synonyms: Aprinox® | Naturetin®
Approved drug
bendroflumethiazide is an approved drug (FDA (1959))
Compound class: Synthetic organic
Comment: Bendroflumethiazide is a thiazide diuretic.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 135.12
Molecular weight 421.04
XLogP 1.73
No. Lipinski's rules broken 0
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Canonical SMILES O=S1(=O)NC(Cc2ccccc2)Nc2c1cc(c(c2)C(F)(F)F)S(=O)(=O)N
Isomeric SMILES O=S1(=O)NC(Cc2ccccc2)Nc2c1cc(c(c2)C(F)(F)F)S(=O)(=O)N
InChI InChI=1S/C15H14F3N3O4S2/c16-15(17,18)10-7-11-13(8-12(10)26(19,22)23)27(24,25)21-14(20-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,20-21H,6H2,(H2,19,22,23)
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Summary of Clinical Use Click here for help
Used to reduce oedema and hypertension.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Believed to inhibit the renal Na-Cl symporter SLC12A3 (thiazide-sensitive sodium-chloride cotransporter), causing increased water excretion via the urinary system.
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