Synonyms: ASL-603 | bretylium tosylate | Bretylol®
bretylium is an approved drug
Compound class:
Synthetic organic
Comment: Bretylium is a substrate for the noradrenaline transporter so it accumulates inside nerve terminals which have this transporter. This accumulation underlies its inhibitory action on the sympathetic nervous system. Bretylium tosylate is no longer available in the US.
![]() View more information in the IUPHAR Pharmacology Education Project: bretylium |
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No information available. |
Mechanism Of Action and Pharmacodynamic Effects ![]() |
May act though inhibition of voltage-gated K+ channels or by binding extracellularly to Na+/K+-ATPases. |