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Synonyms: Frisium® | H-4723 | HR-376 | LM-2717 | Onfi® | Urbanol®
clobazam is an approved drug (FDA (2011))
Compound class: Synthetic organic
Comment: Clobazam is a benzodiazepine drug.
|No information available.|
|Summary of Clinical Use|
|Indicated for the short-term relief of severe, disabling anxiety and may be used as adjunctive therapy in epilepsy.|
|Mechanism Of Action and Pharmacodynamic Effects|
|Clobazol acts as an anxiolytic by allosterically modulating GABAA chloride channels in the CNS, increasing inhibitory GABAergic tone and causing neuro-inhibition of the cortical and limbic systems.
Due to the complex and varied nature of the precise subunit composition of GABAA receptors, and a paucity of affinity data with definitive molecular details, we have not tagged a primary target for this drug.
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)