clobazam   Click here for help

GtoPdb Ligand ID: 7149

Synonyms: Frisium® | H-4723 | HR-376 | LM-2717 | Onfi® | Urbanol®
Approved drug
clobazam is an approved drug (FDA (2011))
Compound class: Synthetic organic
Comment: Clobazam is a benzodiazepine drug.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 40.62
Molecular weight 300.07
XLogP 2.28
No. Lipinski's rules broken 0
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Canonical SMILES Clc1ccc2c(c1)N(C(=O)CC(=O)N2C)c1ccccc1
Isomeric SMILES Clc1ccc2c(c1)N(C(=O)CC(=O)N2C)c1ccccc1
InChI InChI=1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3
No information available.
Summary of Clinical Use Click here for help
Indicated for the short-term relief of severe, disabling anxiety and may be used as adjunctive therapy in epilepsy.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Clobazol acts as an anxiolytic by allosterically modulating GABAA chloride channels in the CNS, increasing inhibitory GABAergic tone and causing neuro-inhibition of the cortical and limbic systems.
Due to the complex and varied nature of the precise subunit composition of GABAA receptors, and a paucity of affinity data with definitive molecular details, we have not tagged a primary target for this drug.
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