Synonyms: Iscover® | Plavix® | SR-25990C
clopidogrel is an approved drug (FDA (1997), EMA (1998))
Compound class:
Synthetic organic
Comment: Clopidogrel is a prodrug converted by liver CYP450 via 2-oxo-clopidogrel to an active metabolite, listed in GtoPdb as clopidogrel (active metabolite) [2]. Marketed formulations may contain clopidogrel bisulfate (PubChem CID 115366).
![]() View more information in the IUPHAR Pharmacology Education Project: clopidogrel |
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No information available. |
Summary of Clinical Use ![]() |
Clopidogrel is used for its anti-clotting action in patients with conditions such as acute coronary syndrome, myocardial infarction, peripheral vascular diseases and stroke. |
Mechanism Of Action and Pharmacodynamic Effects ![]() |
Clopidogrel prevents adenosine diphosphate (ADP) from binding to platelet membrane P2Y12 receptors (P2RY12). This receptor plays a role in platelet aggregation and thrombus formation [1], thus its inhibition reduces the risk of thrombus formation. |
External links ![]() |
For extended ADME data see the following: Drugs.com European Medicines Agency (EMA) |