diethylpropion   Click here for help

GtoPdb Ligand ID: 7161

Synonyms: diethylpropion hydrochloride | Prefamone | Regenon®
Approved drug
diethylpropion is an approved drug (FDA (1959))
Compound class: Synthetic organic
Comment: Diethylpropion is a stimulant drug (of the phenethylamine, amphetamine, and cathinone classes) used for its appetite suppressing action.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 20.31
Molecular weight 205.15
XLogP 2.8
No. Lipinski's rules broken 0
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Canonical SMILES CCN(C(C(=O)c1ccccc1)C)CC
Isomeric SMILES CCN(C(C(=O)c1ccccc1)C)CC
InChI InChI=1S/C13H19NO/c1-4-14(5-2)11(3)13(15)12-9-7-6-8-10-12/h6-11H,4-5H2,1-3H3
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Summary of Clinical Use Click here for help
This drug is used to treat obesity, in combination with diet and exercise.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
As an amphetamine type drug, diethylpropion (or rather its active metabolite, ethcathinone) causes an increase in neuronal catecholamine levels by reducing their re-uptake by inhibiting activity of the dopamine and norepinephrine transporters (SLC6A3 and SLC6A2 respectively). Increasing catecholamine signalling suppresses CNS hunger signals and appetite. Amphetamines may also modulate leptin and neuropeptide Y levels, two peptides which affect feelings of satiety, eating behaviour, energy expenditure and fat storage.