diphenidol   Click here for help

GtoPdb Ligand ID: 7163

Synonyms: K-478-A | SK&F-478-J | SK&F-478A | SK-478 | Vontrol®
Approved drug
diphenidol is an approved drug
Compound class: Synthetic organic
Comment: Diphenidol is a muscarinic antagonist , antiemetic and antivertigo drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 23.47
Molecular weight 309.21
XLogP 4.31
No. Lipinski's rules broken 0
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Canonical SMILES OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1
Isomeric SMILES OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1
InChI InChI=1S/C21H27NO/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22/h1-2,4-7,11-14,23H,3,8-10,15-18H2
No information available.
Summary of Clinical Use Click here for help
Diphenidol is used as an antiemetic. This drug is not approved for clinical use in the US or EU. Other national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
ChEMBL list this drug as an antagonist of the muscarinic acetylcholine receptor M1 (CHRM1), but its precise mechanism of action is poorly understood. See the DrugBank link for further details.