dipivefrine   Click here for help

GtoPdb Ligand ID: 7166

Synonyms: Propine®
Approved drug
dipivefrine is an approved drug
Compound class: Synthetic organic
Comment: Dipivefrin is a prodrug of adrenaline/epinephrine.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 84.86
Molecular weight 351.2
XLogP 1.72
No. Lipinski's rules broken 0
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Canonical SMILES CNCC(c1ccc(c(c1)OC(=O)C(C)(C)C)OC(=O)C(C)(C)C)O
Isomeric SMILES CNCC(c1ccc(c(c1)OC(=O)C(C)(C)C)OC(=O)C(C)(C)C)O
InChI InChI=1S/C19H29NO5/c1-18(2,3)16(22)24-14-9-8-12(13(21)11-20-7)10-15(14)25-17(23)19(4,5)6/h8-10,13,20-21H,11H2,1-7H3
No information available.
Summary of Clinical Use Click here for help
Used to treat glaucoma. There is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
This drug is an adrenoceptor agonist. The DrugBank entry indicates that the drug reduces aqueous humour production and increases outflow to achieve reduced intraocular pressure in glaucoma.