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dyclonine is an approved drug (FDA (date unknown))
Compound class: Synthetic organic
Comment: Dyclonine is a local anesthetic.
Marketed formulations contain dyclonine hydrochloride (PubChem CID 68304).
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.|
|Summary of Clinical Use|
|Dyclonine is the active ingredient in lozenges and throat sprays used to treat minor pain in the mouth and throat (eg Sucrets® and Cepacol®)|
|Mechanism Of Action and Pharmacodynamic Effects|
|This drug stabilises the neuronal membrane by binding to sodium channels, and decreasing permeability to Na+ ions. This blocks initiation and conductance of nerve impulses. ChEMBL report that this drug acts by blocking sodium channel α subunits. The genes SNC1A-SNC11A are listed in this database in the Voltage-gated sodium channels section.|