ethopropazine   Click here for help

GtoPdb Ligand ID: 7181

Synonyms: Parsidol®
Approved drug
ethopropazine is an approved drug
Compound class: Synthetic organic
Comment: Ethopropazine is a phenothiazine derivative drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 31.78
Molecular weight 312.17
XLogP 5.25
No. Lipinski's rules broken 1
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Canonical SMILES CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC
Isomeric SMILES CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC
InChI InChI=1S/C19H24N2S/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21/h6-13,15H,4-5,14H2,1-3H3
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Summary of Clinical Use Click here for help
Used to treat the dyskinesia typical of Parkinson's disease. There is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
By antagonising the muscarinic acetylcholine M1 receptor, ethopropazine is believed to correct the imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum associated with Parkinsonism.