ethotoin   Click here for help

GtoPdb Ligand ID: 7183

Synonyms: Peganone®
Approved drug
ethotoin is an approved drug (FDA (1957))
Compound class: Synthetic organic
Comment: Ethotoin is an anticonvulsant drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 52.9
Molecular weight 204.09
XLogP 1.41
No. Lipinski's rules broken 0
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Canonical SMILES CCN1C(=O)C(N=C1O)c1ccccc1
Isomeric SMILES CCN1C(=O)C(N=C1O)c1ccccc1
InChI InChI=1S/C11H12N2O2/c1-2-13-10(14)9(12-11(13)15)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H,12,15)
No information available.
Summary of Clinical Use Click here for help
Ethotoin may be used to treat epileptic seizures.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
This drug likely blocks sodiun channel α subunits. This appears to reduce seizure propagation and limit the spread of seizure activity in the brain. See the DrugBank link for further details.
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