ketotifen   Click here for help

GtoPdb Ligand ID: 7206

Synonyms: HC-20511 | Zaditor®
Approved drug
ketotifen is an approved drug (FDA (1999))
Compound class: Synthetic organic
Comment: Ketotifen is an antihistamine. This drug may be used in eye drop or oral formulations, where the active ingredient is ketotifen fumarate (PubChem CID 5282408).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 48.55
Molecular weight 309.12
XLogP 2.46
No. Lipinski's rules broken 0
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Canonical SMILES CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1
Isomeric SMILES CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1
InChI InChI=1S/C19H19NOS/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19/h2-5,8,11H,6-7,9-10,12H2,1H3
No information available.
Summary of Clinical Use Click here for help
Ketotifen is used for the symptomatic relief of allergic conditions including rhinitis and conjunctivitis.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Ketotifen blocks the action of endogenous histamine at the histamine H1 receptor.
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