mechlorethamine

Ligand id: 7218

Name: mechlorethamine

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View more information in the IUPHAR Pharmacology Education Project: mechlorethamine

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 3.24
Molecular weight 155.03
XLogP 1.59
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the palliative care of patients with various cancers. Ledaga® was EMA approved in 2017 as a treatment for mycosis fungoides-type cutaneous T-cell lymphoma, having been granted EMA orphan designation in 2012 for the treatment of cutaneous T-cell lymphoma.
Mechanism Of Action and Pharmacodynamic Effects
Mechlorethamine is a potent DNA alkylating (cross-linking) agent. Treatment with this drug irreversibly interferes with DNA replication, RNA transcription and general disruption of nucleic acid function. This action causes cell death. Due to the complex and varied nature of nucleic acids we do not include DNA or RNA as targets on this database.
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