Ligand id: 7226

Name: mercaptopurine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: 6-mercaptopurine

Structure and Physico-chemical Properties

2D Structure
Click here for structure editor
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 93.26
Molecular weight 152.02
XLogP 0.22
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Mercaptopurine is used to treat acute leukemia.
Mechanism Of Action and Pharmacodynamic Effects
Mercaptopurine is a purine analogue which interferes with nucleic acid biosynthesis. ChEMBL also cite amidophosphoribosyltransferase (PPAT, Q06203) as a target of this drug. This enzyme catalyses the first step in de novo purine synthesis.
External links