methixene   Click here for help

GtoPdb Ligand ID: 7232

Synonyms: metixene | SJ-1977 | Trest®
Approved drug
methixene is an approved drug
Compound class: Synthetic organic
Comment: Methixene is an antihistamine drug, with anticholinergic activity. There is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 28.54
Molecular weight 309.16
XLogP 4.69
No. Lipinski's rules broken 0
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Canonical SMILES CN1CCCC(C1)CC1c2ccccc2Sc2c1cccc2
Isomeric SMILES CN1CCCC(C1)CC1c2ccccc2Sc2c1cccc2
InChI InChI=1S/C20H23NS/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20/h2-5,8-11,15,18H,6-7,12-14H2,1H3
No information available.
Summary of Clinical Use Click here for help
Anticholinergic activity is used to treat Parkinson disease, hyperactivity, anxiety and insomnia. The drug is also used to treat allergy symptoms.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Methixene blocks the action of endogenous histamine at the histamine H1 receptor. Anticholinergic activity underlies the drugs additional actions.