olopatadine   Click here for help

GtoPdb Ligand ID: 7249

Synonyms: ALO-4943A | KW-4679 | Opatanol® | Patanol® | Pazeo®
Approved drug Immunopharmacology Ligand
olopatadine is an approved drug (FDA (1996), EMA (2002))
Compound class: Synthetic organic
Comment: Olopatadine is an antihistamine.
Marketed formulations may contain olopatadine hydrochloride (PubChem CID 5282402).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 49.77
Molecular weight 337.17
XLogP 3.42
No. Lipinski's rules broken 0
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Canonical SMILES CN(CCC=C1c2cc(ccc2OCc2c1cccc2)CC(=O)O)C
Isomeric SMILES CN(CC/C=C/1\c2cc(ccc2OCc2c1cccc2)CC(=O)O)C
InChI InChI=1S/C21H23NO3/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24)/b18-8-
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Summary of Clinical Use Click here for help
Olopatadine is contained in opthalmic solutions used to treat the symptoms of seasonal allergic conjunctivitis, including itching, redness and swelling.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Olopatadine blocks the action of endogenous histamine at the histamine H1 receptor.
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