phenelzine   Click here for help

GtoPdb Ligand ID: 7266

Synonyms: Nardil® | phenelzine sulfate
Approved drug
phenelzine is an approved drug (FDA (1961))
Compound class: Synthetic organic
Comment: Phenelzine is a monoamine oxidase inhibitor (MAOI).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 38.05
Molecular weight 136.1
XLogP 1.08
No. Lipinski's rules broken 0
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Canonical SMILES NNCCc1ccccc1
Isomeric SMILES NNCCc1ccccc1
InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2
No information available.
Summary of Clinical Use Click here for help
Used to treat depression.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
MAOIs increase presynaptic levels of monoamines by inhibiting their catabolism after presynaptic reuptake. Therefore, inhibiting MAOs, increases the levels of serotonin and catecholamine neurotransmitters (epinephrine, norepinephrine, and dopamine) in neurones of the central and sympathetic nervous systems. This action appears to restore the relative deficiencies of catecholamines or suppressed serotonin/norepinephrine signalling postulated to be causative in depressive conditions.
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