procarbazine   Click here for help

GtoPdb Ligand ID: 7278

Synonyms: Matulane® | Ro-4-6467/1 | Ro-4646711
Approved drug
procarbazine is an approved drug (FDA (1969))
Compound class: Synthetic organic
Comment: Procarbazine is a DNA alkylating agent.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 53.16
Molecular weight 221.15
XLogP 2.58
No. Lipinski's rules broken 0
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Canonical SMILES CNNCc1ccc(cc1)C(=O)NC(C)C
Isomeric SMILES CNNCc1ccc(cc1)C(=O)NC(C)C
InChI InChI=1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,13-14H,8H2,1-3H3,(H,15,16)
No information available.
Summary of Clinical Use Click here for help
Used as a component of treatment for Hodgkin's disease (lymphadenoma) and some other cancers.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
As a DNA alkylating (cross-linking) agent, procarbazine treatment irreversibly interferes with DNA replication, RNA transcription and general disruption of nucleic acid function. This action causes cell death. The drug may have additional actions, see the DrugBank link for further details. Due to the complex and varied nature of nucleic acids we do not include DNA or RNA as targets on this database.
External links Click here for help