prochlorperazine   Click here for help

GtoPdb Ligand ID: 7279

Synonyms: Buccastem® | Compazine® | prochlorperazine edisylate | prochlorperazine maleate
Approved drug PDB Ligand
prochlorperazine is an approved drug (FDA (1956))
Compound class: Synthetic organic
Comment: Prochlorperazine is a potent phenothiazine neuroleptic.
Click here for help
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: prochlorperazine

2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 35.02
Molecular weight 373.14
XLogP 4.57
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2
Isomeric SMILES CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2
InChI InChI=1S/C20H24ClN3S/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24/h2-3,5-8,15H,4,9-14H2,1H3
No information available.
Summary of Clinical Use Click here for help
Used as an anti-psychotic medication to treat disorders such as schizophrenia, acute mania and anxiety. It also has antiemetic action.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
This drug’s molecular mechanism of action (MMOA) is complex and not fully resolved. The MMOA may be, in part, caused by the drug's anti-dopaminergic activity. See the DrugBank link for further details.
External links Click here for help