pyrazinamide   Click here for help

GtoPdb Ligand ID: 7287

Synonyms: aldinamide | Zinamide®
Approved drug PDB Ligand
pyrazinamide is an approved drug (FDA (no history prior to 1971))
Compound class: Synthetic organic
Comment: This drug is often contained in fixed-mixture formulations with other antibacterial drugs beneficial in the treatment of tuberculosis (eg isoniazid and rifampicin).
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 69.86
Molecular weight 123.04
XLogP -0.37
No. Lipinski's rules broken 0
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Canonical SMILES OC(=N)c1cnccn1
Isomeric SMILES OC(=N)c1cnccn1
InChI InChI=1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)
No information available.
Summary of Clinical Use Click here for help
Used to treat tuberculosis.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Reduces Mycobacterium tuberculosis infection level by inhibiting the 70S ribosome and fatty acid synthase critical for mycobacterial growth. It has bacteriostatic rather than bacteriocidal action.
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