temazepam   Click here for help

GtoPdb Ligand ID: 7300

Synonyms: Restoril® | WY-3917
Approved drug
temazepam is an approved drug (FDA (1981))
Compound class: Synthetic organic
Comment: Temazepam is a benzodiazepine drug, with sedative and hypnotic actions.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 52.9
Molecular weight 300.07
XLogP 2.99
No. Lipinski's rules broken 0
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Canonical SMILES Clc1ccc2c(c1)C(=NC(C(=O)N2C)O)c1ccccc1
Isomeric SMILES Clc1ccc2c(c1)C(=NC(C(=O)N2C)O)c1ccccc1
InChI InChI=1S/C16H13ClN2O2/c1-19-13-8-7-11(17)9-12(13)14(18-15(20)16(19)21)10-5-3-2-4-6-10/h2-9,15,20H,1H3
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Summary of Clinical Use Click here for help
Used to treat insomnia. In addition, temazepam may be used as a pre-operative sedative (anxiolytic action).
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Temazepam positively modulates the activity of GABAA anion channels. The drug increases inhibitory GABAergic tone and causes neuro-inhibition. Drug-induced effects are observed clinically as anxiolytic, sedative, anticonvulsant and skeletal muscle relaxant actions.
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