triazolam   Click here for help

GtoPdb Ligand ID: 7313

Synonyms: Halcion® | U-33030
Approved drug
triazolam is an approved drug (FDA (1982))
Compound class: Synthetic organic
Comment: Triazolam is a benzodiazepine.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 42.55
Molecular weight 342.04
XLogP 6.12
No. Lipinski's rules broken 1
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Canonical SMILES Clc1ccc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl
Isomeric SMILES Clc1ccc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl
InChI InChI=1S/C17H12Cl2N4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3
No information available.
Summary of Clinical Use Click here for help
Used as a sedative to treat severe insomnia. The drug also has amnesic, anxiolytic, sedative, anticonvulsant and muscle relaxant properties.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Triazolam positively modulates the activity of GABAA anion channels. The drug increases inhibitory GABAergic tone and causes neuro-inhibition. Drug-induced effects are observed clinically as anxiolytic, sedative, anticonvulsant and skeletal muscle relaxant actions.
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