hydralazine   Click here for help

GtoPdb Ligand ID: 7326

Synonyms: Apresoline®
Approved drug PDB Ligand
hydralazine is an approved drug (FDA (1953))
Compound class: Synthetic organic
Comment: Hydralazine is a hydrazinophthalazine class anti-hypertensiove drug.
Hydralazine is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 0
Topological polar surface area 67.06
Molecular weight 160.07
XLogP 1.58
No. Lipinski's rules broken 0
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Canonical SMILES NN=c1[nH]ncc2c1cccc2
Isomeric SMILES NN=c1[nH]ncc2c1cccc2
InChI InChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12)
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Summary of Clinical Use Click here for help
Used to treat hypertension and severe congestive cardiac failure.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The molecular mechanism of action of this drug has not been fully resolved, but appears to involve vasodilatory action which improves cardiac oxygenation and reduces its workload. See the DrugBank link for further details.
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